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Affiliation with medical organization:

Surgical Society, ROC
Society of Colon and Rectal Surgeons, ROC

Licensures:

醫師證書 醫字第029387 號
外科專科醫師證書 外專醫字第004861 號
中華民國大腸直腸外科醫學會專科醫師證書 大直外醫證字第236 號
腫瘤外專科醫師證書 中腫外專醫證字第101100 號
腫瘤外科專科醫師訓練指導聘書 中腫外專聘字第101165 號
部定助理教授證書 助理字第039465 號

歷年著作

Publications：* Corresponding Author

1. Han-Hsiang Chen*, Shyr-Ming Sheen Chen, Chien-Chang Lu. DNA Index andS-phase Fraction in Curative Resection of Colorectal Adenocarcinoma: Analysis of Prognosis and Current Trends. World Journal of Surgery. 2002 May, Vol.26(5):626-630. (SCI; IF=2.362; Surgery 48/199)
2. Chien-Chang Lu, Hong-Hwa Chen*, Chia-Lo Chang. Comparison of weekly and bi-weekly schedules of irinotecan, leucovorin, and infusional fluorouracil in patients with stage IV colorectal cancer. J Soc Colon Rectal Surgeon (Taiwan). 2004 Jun, Vol.15:75-82.
3. Chien-Chang Lu, Hong-Hwa Chen*, Ming-Jang Hsieh. Wandering spleen presenting as gastric outlet obstruction after repair of traumatic diaphragmatic hernia. Journal of Trauma-Injury Infection and Critical Care. 2004 Feb, Vol.56 (2):431-432.(SCI; IF=2.478; Surgery 44/199)
4. Wang-Hseng Wu, Hong-Hwa Chen*, Shang-Eing Lin, Chia-Lo Chang,Chien-Chang Lu. Oxaliplatin in combination with 5-fluorouracil and leucovorin as second-line therapy for metastatic colorectal cancer. J Soc Colon Rectal Surgeon(Taiwan). 2004 Dec; Vol.15:119-126.
5. Ching-Hsiang Yang, Shyr-Ming Sheen-Chen*, Chien-Chang Lu, Sheung-Fat Ko and Hock-Liew Eng. Computed tomographic presentation of mesenteric fibromatosis. Digestive Diseases and Sciences. 2005 Feb, Vol.50 (2):348-350. (SCI; IF=2.117;Gastroenterology & Hepatology 42/74)
6. Ko-Chao Lee, Hong-Hwa Chen*, Shung-eing Lin, Chia-Lo Chang,Chien-Chang Lu, Wang-Hseng Hu. Ischemic colitis: experience in Kaohsiung ChangGung Memorial Hospital. J Soc Colon Rectal Surgeon (Taiwan). 2006 Mar,Vol.7:7-12
7. Chen-I Wu, Ching-Chou Tsai, Chien-Chang Lu, Pei-Chang Wu, Deng-Chyang Wu, Shu-Yao Lin, Jentaie Shiea*. Diagnosis of occult blood in human feces using matrix-assisted laser desorption ionization/time-of-flight mass spectrometry. Clinica Chimica Acta. 2007 Sep, Vol.384 (1-2):86-92. (SCI; IF=2.535; Medical LaboratoryTechnology 6/32)
8. Chung-Chi Huang, Hong Hwa Chen*, Shung-eing Lin, Chia-Lo Chang,Chien-Chang Lu, Wang-Hseng Hu, Ko-Chao Lee. Surgical management of complete rectal prolapse. J Soc Colon Rectal Surgeon (Taiwan). 2007 Dec, Vol.18:99-104
9. Yoke-Hong Yee, Chien-Chang Lu, Fu-Tsai Kung, Kuan-Hui Huang*.Rectocutaneous fistula: a rare complication of the posterior intravaginal sling. Int Urogynecol J. 2008 Apr, Vol.19 (4):599-601. (SCI; IF=1.832; Obsteterics & Gynecology 30/79)
10. Shi-Guo Liang, Hong-Hwa Chen*, Shung-Eing Lin, Chia-Lo Chang,Chien-Chang Lu, Wang-Hseng Hu. Fournier’s Gangrene in female patients. J Soc Colon Rectal Surgeon (Taiwan). 2008 Jun, Vol.19 (2):57-64
11. Li-Chin Cheng, Hong-Hwa Chen*, Shung-Eing Lin, Chia-Lo Chang,Chien-Chang Lu, Wang-Hseng Hu, Ko-Chao Lee. Hypersensitivity reactions to Oxaliplatin: a prospectively collected study of 25 cases treated in one institute. J Soc Colon Rectal Surgeon (Taiwan). 2008 Dec,Vol.19(4):115-122.
12. Chien-Chang Lu, Hong-Hwa Chen*, Shung-Eing Lin. Ischemic versus non-ischemic obstructive lleocolitis secondary to colorectal cancer: A review of 393 cases. Jpn J Clin Oncol. 2010 Oct, Vol.40 (10):927-932. (SCI; IF=1.783; Oncology 135/196)
13. Ko-Chao Lee, Wang-Hseng Hu, Chien-Chang Lu, Chia-Lo Chang, Shung-Eing Lin, Hong-Hwa Chen, Wen-Sy Tsai*. Clinical Outcome of Salvage Surgery for Stage III Patients with Recurrent Colorectal Cancer. J Soc Colon Rectal Surgeon (Taiwan).2010 Dec.; Vol.21, No.4; p155-160.
14. Keng-Liang Wu, Christopher K. Rayner, M.B.B.S., Seng-Kee Chuah,King-Wah Chiu, Chien-Chang Lu, Yi-Chun Chiu. Impact of Low-Residue Diet on Bowel Preparation for Colonoscopy. Diseases of the Colon & Rectum. 2011 Jan,Vol.54 (1): 107-112. (SCI; IF=3.132; Surgery 20/199)
15. Kai-Lung Tsai, Chien-Chang Lu*, Hong-Hwa Chen, Shung-Eing Lin.Overview of Radiation-Related Colovesical or Rectovesical Fistula: Experience from 18 Patients at the Chang Gung Memorial Hospital in Kaohsiung. J Soc Colon Rectal Surgeon (Taiwan). 2011 Sep; Vol. 22;p79-85.
16. Chien-Chang Lu*, Shung-Eing Lin, Kuan-Chih Chung, Kun-Ming Rau.Comparison of c linical outcome of single incision laparoscopic surgery using a simplified access system with conventional laparoscopic surgery for malignant colorectal disease. Colorectal Disease. 2012 Apr, Vol. 14(4): e171-e176. (SCI; IF=2.017; Surgery 69/204)
17. Yueh-Jung Wu, Chien-Chang Lu, Shung-Eing Lin, Chia-Lo Chang,Wang-Hseng Hu, Ko-Chao Lee, Hong-Hwa Chen*. Treatment Response in Patients with Primary Colonic Lymphomas: Experience in a Single Institute. J Soc Colon Rectal Surgeon (Taiwan). 2012 Jun; Vol.23, No.2; p39-47.
18. Rau KM, Huang CC, Chiu TJ, Chen YY, Lu CC, Liu CT, Pei SN, Wei YC.Neovascularization evaluated by CD105 correlates well with prognostic factors in breast cancers. Exp Ther Med. 2012 Aug; 4(2): 231-236. (SCI; IF=0.344; Medicine,Research & Experimental 109/121)
19. Chung KC, Juang SE, Lee KC, Hu WH, Lu CC, Lu HF, Hung KC*. The effect of pre-procedure anxiety on sedative requirements for sedation during colonoscopy.Anaesthesia. 2013 Mar; 68(3): 253-9. (SCI; IF=3.846; Anesthesiology 4/29)
20. Yueh-Ming Lin, Ko-Chao Lee, Kai-Lung Tsai, Shung-Eing Lin, Hong-Hwa Chen, Chien-Chang Lu*. Single Incision Laparoscopic Colectomy for Benign ColonDiseases. J Soc Colon Rectal Surgeon (Taiwan). 2013 Jun; Vol.24: 57-64.
21. Ko-Chao Lee, Hong-Hwa Chen, Kuan-Chih Chung, Wang-Hseng Hu, Chia-Lo Chang, Shung-Eing Lin, Kai-Lung Tsai, Chien-Chang Lu*. Meta-analysis of randomized controlled trials comparing outcomes for stapled hemorrhoidopexy versus LigaSure hemorrhoidectomy for symptomatic hemorrhoids in adults. Int J Surg. 2013; 11(9):914-8. (SCI; IF=1.650; Surgery 86/204)
22. Lin YM, Chen HH, Chen YJ, Chen PH, Lu CC*. Single-incision laparoscopic colectomy using self-made glove port for benign colon diseases. J of Laparoendoscopic & Advanced Surgical Techniques. 2013 Nov; 23(11): 932-7. (SCI;IF=1.187; Surgery 126/204)
23. Chien-Heng Shen, Shui-Yi Tung, Wen-Shih Huang, Chien-Chang Lu,Ko-Chao Lee, Yung-Yu Hsieh, Pey-Jium Chang, Hwey-Fang Liang, Jiann-Hwa Chen,Tseng-Hsi Lin, Meng Chiao Hsieh, Kuo Hsing-Chun*. Exploring the effects of tert-butylhydroperoxide induced liver injury using proteomic approach. Toxicology.2014 Feb 28; 316:61-70. (SCI; IF=3.745; Toxicology 16/187)
24. Lee KF, Chen JH, Teng CC, Shen CH, Hsieh MC, Lu CC, Lee KC, Lee LY,Chen WP, Chen CC, Huang WS, Kuo HC*. Protective Effects of Hericium erinaceus Mycelium and Its Isolated Erinacine A against Ischemia-Injury-Induced Neuronal Cell Death via the Inhibition of iNOS/p38 MAPK and Nitrotyrosine. Int J Mol Sci. 2014 Aug; 15(9):15073-15089. (SCI; IF=2.339; Chemistry 45/157)
25. Lai WH, Lin YM, Lee KC, Chen HH, Chen YJ, Lu CC*. The Application of McBurney's Single-Incision Laparoscopic Colectomy Alleviates the Response of Patients to Postoperative Wound Pain. J Laparoendoscopic & Advanced Surgical Techniques. 2014 Sep; 24: 606-611. (SCI; IF=1.187; Surgery 126/204)
26. Lu CC*, Kuo HC, Wang FS, Jou MH, Lee KC, Chuang JH*. Upregulation of TLRs and IL-6 as a marker in human colorectal cancer. Int J Mol Sci. 2015 Jan; 24;16(1): 159-77. (SCI; IF=4.556; Biochemistry & Molecular Biology 74/297)
27. Lee KC*, Lu CC, Hu WH, Lin SE, Chen HH*. Colonoscopic diagnosis of amebiasis: a case series and systematic review. Int J Colorectal Dis. 2015 Jan; 30(1):31-41. (SCI; IF=2.108; Surgery 88/210)
28. Lu LS, Lu CC, Tai WC, Tsai KL*, Huang CC, Wu KL, Chiu YC, Chuah SK.Clinical analysis on endoscopic and surgical treatment outcome of colonic lipomas: a 12-rear study in southern Taiwan. J Soc Colon Rectal Surgeon (Taiwan). 2015 Mar;Vol. 26(1): p1-7.
29. Chia-Cheng Liu, Hong-Hwa Chen, Wan-Hsiang Hu, Shung-Eing Lin, Chia-LoChang, Chien-Chang Lu, Ko-Chao Lee* . Abnormality of appendix in incidental appendectomy during colorectal cancer surgery. J Soc Colon Rectal Surgeon (Taiwan).2015; 26: 14-21.
30. Ko-Chao Lee, Chien-Chang Lu*, Shung-Eing Lin, Chia-Lo Chang, Hong-Hwa Chen. Infiltration of local anesthesia at wound site after single-incision laparoscopic colectomy reduces postoperative pain and analgesic usage. Hepato-gastroenterology.2015 Jun; 62(140):811-6. (SCI)
31. Wen-Shih Huang , Jen-Tsung Yang , Chien-Chang Lu, Shun-Fu Chang Cheng-Nan Chen, Yu-Ping Su, Ko-Chao Lee*. Fulvic Acid Attenuates Resistin-Induced Adhesion of HCT-116 Colorectal Cancer Cells to Endothelial Cells.Int. J. Mol. Sci. 2015 Dec 9; 16(12): 29370–29382. (SCI; IF=4.556; Biochemistry & Molecular Biology 74/297)
32. Ching-Hsien Wang, Yueh-Ming Lin, Hong-Hwa Chen, Chia-Lo Chang,Ko-Chao Lee, Kai-Lung Tsai, Chien-Chang Lu*. Single-incision Laparoscopic Surgery Versus Conventional Laparoscopy for Colorectal Cancer: A Comparison of Oncologic Outcomes. J Soc Colon Rectal Surgeon (Taiwan). 2015 Dec; 26(4):142-149.
33. Hsing-Chun Kuo, Chien-Chang Lu, Chien-Heng Shen, Shui-Yi Tung, Meng ㄙChiao Hsieh, Ko-Chao Lee, Li-Ya Lee, Chin-Chu Chen, Chih-Chuan Teng, Wen-ShihHuang, Te-Chuan Chen, Kam-Fai Lee*. Hericium erinaceus mycelium and its isolated Erinacine A protection from MPTP-induced neurotoxicity through the ER stress,triggering an apoptosis cascade. J Transl Med. 2016 Mar 18; 14(1):78. doi:10.1186/s12967-016-0831-y. (SCI; IF=4.124; Medicine, Research & Experimental 45/139)
34. Chien-Chang Lu,Wen-Shih Huang, Kam-Fai Lee, Ko-Chao Lee, Meng-Chiao Hsieh, Cheng-Yi Huang, Li-Ya Lee, Bih-O. Lee, Chih-Chuan Teng,Chien-Heng Shen,Shui-Yi Tung, Hsing-Chun Kuo*. Inhibitory effect of Erinacines A on the growth ofDLD-1 colorectal cancer cells is induced bygeneration of reactive oxygen species andactivation of p70S6K and p21.J Funct Foods. 2016 Mar 21: 474–484. (SCI;IF=3.701; Food Science & Techn ology 31/139)
35. Kung-Chuan Cheng, Hong-Hwa Chen, Chia-Lo Chang, Wan-Hsiang Hu,Ko-ChaoLee, Kai-Lung Tsai, Yueh-Ming Lin, Eng-Yen Huang, Hsuan-Chih Hsu,Chien-Chang Lu*. Prolonging the Interval between Neoadjuvant Concurrent Chemoradiotherapy and Surgery Improves Pathological Outcomesin Rectal Cancer. J Soc Colon Rectal Surgeon (Taiwan). 2016; 27: 119-126.
36. Ling-Chiao Song, Yu-Che Ou, Hong-Hwa Chen, Shung-Eing Lin,Chien-Chang Lu, Wan-Hsiang Hu, Ko-Chao Lee*. Metachronous Krukenberg Tumors from Colorectal Cancer ― a 12-year Study in A Medical Center. J Soc Colon Rectal Surgeon (Taiwan). 2017; 28: 94-100.
37. Kuen-Lin Wu, Ko-Chao Lee*, Chia-Cheng Liu, Hong-Hwa Chen,Chien-Chang Lu. Laparoscopic versus open surgery for diverticulitis: a systematic review and meta-analysis. Dig Surg. 2017; 34(3):203-215. (SCI; IF=2.167; Surgery 84/210)
38. Wu KL, Lin YM, Lu CC*. Analysis of Risk Factors for Conversion of Single Incision Laparoscopic Surgery for Colorectal Disease. J Soc Colon Rectal Surgeon(Taiwan). 2017 Jun; Vol.28, No.2; p73-79.
39. Ko-Chao Lee (co-first), Kuan-Chih Chung*, Hong-Hwa Chen, Chia-Cheng Liu,Chien-Chang Lu. Prognostic factors of overall survival and cancer-specific survival in patients with resected early stage rectal adenocarcinoma: a SEER-based study. J Investig Med. 2017.Dec; 65(8):1148-1154. doi: 10.1136/jim-2017-000496. (SCI;IF=2.304; Medicine, General & Internal 60/165)
40. Ko-Chao Lee, Hsing-Chun Kuo, Chien-Heng Shen, Chien-Chang Lu,Wen-Shih Huang, Meng-Chiao Hsieh, Cheng-Yi Huang, Yi-Hung Kuo, Kam-Fai Lee,Chih-Chuan Teng, Li-Ya Lee, Shui-Yi Tung*. A proteomics approach to identifying novel protein targets involved in erinacine A mediated inhibition of colorectal cancer cells aggressiveness. J Cell Mol Med. 2017 Mar; 21(3): 588-599. doi:10.1111/jcmm.13004. (SCI; IF=4.486; Medicine, Research & Experimental 36/139)
41. Chang LS, Hsu YW, Lu CC, Lo MH, Hsieh KS, Li Chang WC, Kuo HC.CYP2E1 Gene Polymorphisms Related to the Formation of Coronary Artery Lesions in Kawasaki Disease. Pediatric Infect Dis J. 2017 Nov; 36(11):1039-1043. (SCI;IF=2.126; Pediatrics 46/128)
42. Ko-Chao Lee, Chih-Chuan Teng, Chien-Heng Shen, Wen-Shih Huang,Chien-Chang Lu, Hsing-Chun Kuo, Shui-Yi Tung*. Protective effect of black garlic extracts on tert-Butyl hydroperoxide-induced injury in hepatocytes via a c-Jun N-terminal kinase-dependent mechanism. Exp TherMed. 2018 Mar; 15(3):2468-2474.doi: 10.3892/etm.2018. 5719. Epub 2018 Jan 8. (SCI; IF=1.785; Medicine, Research& Experimental 105/139)
43. Yueh-Ming Lin, Chih-I Chen, Yi-Ping Hsiang, Yung-Chia Hsu, Kung-Chuan Cheng, Pei-Hsuan Chien, Hsiao-Lin Pan, Chien-Chang Lu(co-corresponding)*, Yun-Ju Chen* . Chrysin Attenuates Cell Viability of Human Colorectal Cancer Cells through Autophagy Induction Unlike 5-Fluorouracil/Oxaliplatin. Int J of Molecular Sci. 2018 Jun; 19(6): 1763. (SCI;IF=4.556; Biochemistry & Molecular Biology 74/297)
44. Ko-Chao Lee*, Kuan-Chih Chung, Hong-Hwa Chen, Kung-Chuan Cheng, Kuen-Lin Wu, Chien-Chang Lu. Short-term postoperative outcomes of colorectal cancer among patients with chronic liver disease: a national population-based study. BMJ Open. 2018 Jun; 8:e20511. (SCI; IF=2.496; Medicine,General & Internal 52/165)
45. Kai-Lung Tsai*, Wei-Hung Lai, Ko-Chao Lee, Shung-Eing Lin, Chia-Lo Chang,Chien-Chang Lu, Wan-Hsiang Hu, Seng-Kee Chuah, and Hong-Hwa Chen*.Long-Term Consequences of Nonclosure of Mesenteric Defects after Traditional Right Colectomy. 2018 Sep; 2018: 9123912. BioMed Research Int. (SCI; 2.276;Biotechnology & Applied Microbiology 92/156)
46. Ko-Chao Lee, Chia-Cheng Liu, Wan-Hsiang Hu, Chien-Chang Lu, Shung-Eing Lin, and Hong-Hwa Chen*. Risk of delayed bleeding after hemorrhoidectomy. Int J Colorecta Dis. 2019 Feb; 34(2): 247-253. (SCI; IF=2.108; Surgery 88/210)
47. Yueh-Ming Lin , Chien-Chang Lu , Yi-Ping Hsiang , Shu-Chuan Pi , Chih-I Chen , Kung-Chuan Cheng , Hsiao-Lin Pan , Pei-Hsuan Chien , Yun-Ju Chen*. c-Met inhibition is required for the celecoxib-attenuated stemness property of human colorectal cancer cells. J Cell Physiol. 2019 Jul; 234(7): 10336-10344. (SCI; IF=5.546;Physiology 7/81)
48. Chen CH, Liang CM, Lu CC, Liu YW, Lu SN, Hung CH. Prognostic factors of radiofrequency ablation therapy for liver metastases from colorectal cancer. Adv Dig Med. 2019 Sep; 6:101-108.
49. Liu, Yueh-Wei; Lu, Chien-Chang; Chang, Ching-Di; Lee, Ko-Chao; Chen,Hong Hwa; Yeh, Wen Shuo; Hu, Wang-Hseng; Tsai, Kai-Lung; Yeh, Cheng-Hsi;Wee, Sin-Yong; Yin, Shin-Min; Wang, Chih-Chi; Hung, Chao-Hung*. Prognostic value of sarcopenia in patients with colorectal liver metastases undergoing hepatic resection. Scientific Reports. 2020 April; 10: 6459. (SCI; IF=3.998; MultidisciplinarySciences 17/71)